Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.

By R. Moreau, R. Jalan, P. Ginés, M. Pavesi, P. Angeli, J. Córdoba, F. Durand, T. Gustot, F. Saliba, M. Domenicali and 8 more. Gastroenterology, 2013

2,794 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/a45b4732621623d037f32870e087a3ee72156bd2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. P. Ginés
2. M. Bernardi
3. W. Laleman
4. P. Angeli
5. J. Trebicka
6. G. Garcia‐Tsao
7. A. Sanyal
8. P. Kamath

In Hepatology

1. P. Ginés
2. M. Bernardi
3. P. Angeli
4. W. Laleman
5. J. Trebicka
6. Rajeshwar P. Mookerjee
7. G. Garcia‐Tsao
8. A. Sanyal

Citations in the corpus

• Systemic inflammation in decompensated cirrhosis: Characterization and role in acute‐on‐chronic liver failure (2016, methodology): “The third approach included two different analyses: (1) a logistic regression model to assess which markers (IL-8, IL-6, HNA2, and/or PRC) were independently associated with the presence of ACLF or ACLF-RF and (2) a linear regression model assessing the correlation of IL-8, IL-6, HNA2, and PRC with ”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update (2019, methodology): “The EASL-CLIF consortium has defined ACLF in which kidney dysfunction is used as a defining condition [11].”
• Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance. (2014, background): “The clinical expression of bacteria-dependent events during cirrhosis includes both chronic systemic and organ-specific damage and intercurrent acute insults (i.e. acute-on-chronic) [120,121].”
• The Global Burden of Liver Disease: The Major Impact of China (2014, methodology): “The chronic liver failure/sequential organ failure assessment scores are used as a classification system to judge the prognosis of patients (possibility of mortality) and to screen for LT candidates with the most urgent need.(41) In 2104 WANG, FAN, ET AL.”
• Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases (2021, background): “Albumin Bacterial infections in patients with cirrhosis are a common precipitant of acute deterioration leading to worsening hepatic decompensation and multiorgan failure, with the kidney being the most commonly affected organ (190).”
• The Cirrhosis Dysbiosis Ratio defines Changes in the Gut Microbiome Associated with Cirrhosis and its Complications (2013, positive): “We could speculate that this microbiome profile, associated with endotoxemia reflects the microbiota that existed when the patient developed the infection and that this dysbiotic flora could potentiate these subsequent poor outcomes [5,6].”
• Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis (2015, background): “Median delay between ACLF diagnosis and LT was 11 (1-28) days.”
• Acute-on chronic liver failure. (2012, background): “The aim of this study was to assess the concept, prevalence, diagnostic criteria, natural course, and prognosis of ACLF in Europe based on data and not on opinions [5].”
• Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. (2014, methodology): “Among infected patients, systemic inflammation is more marked in patients with ACLF than in those without [76].”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014 (2009, positive): “Another logistic regression model [105] using five independent factors, namely HE, HRS, liver cirrhosis, HBeAg, and PTA, gave an AUC of 0.873, as compared to a MELD AUC of 0.694.”