Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

By Zhi-Li Huang, Wei-min Qu, N. Eguchi, Jiang-fan Chen, M. Schwarzschild, B. Fredholm, Y. Urade, O. Hayaishi. Nature Neuroscience, 2005

628 citations recorded by the source corpus.

Subfields: Clinical Psychology, Cognitive Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/a45903afe02b1a4dde48d9c1350af97e50d5d1d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Philip Haydon
2. Ted Abel
3. Michael M. Halassa

In Physiology

1. B. Fredholm
2. Philip Haydon
3. Kenneth A. Jacobson
4. Maiken Nedergaard
5. Alexei Verkhratsky

Citations in the corpus

• Effects of caffeine on human health (2003, background): “Furthermore, movements can lead to stay awake[22] .”
• International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update (2011, background): “The reasons for this generally large divergence were implicitly examined by Ivanov et al. (2009). The authors noted that domain knowledge such as mutagenesis data yielded useful constraints when docking ZM241385 into a receptor homology model.”
• Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss (2009, methodology): “Astrocytic dnSNARE expression prevented the sleep-suppressing effects of CPT (Figures 3G and S11) but did not affect the sleep-suppressing effects of the A2A antagonist ZM 241385 (Figures 3G and S11), or of caffeine (Figures 3G and S11), which is known to act via A2A receptors in this behavior (Huan”