De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.
By Shoghag Panjarian, L. Kozhaya, S. Arayssi, M. Yehia, J. Bielawski, A. Bielawska, J. Usta, Yusuf A. Hannun, LM Obeid, G. Dbaibo. 2008
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Subfields: Molecular Biology
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Citations in the corpus
- Mammalian Ceramide Synthases (2010, background): “Similarly, in response to p53, C16-ceramide levels were increased in leukemia and colon cancer cells, as were levels of CerS5 mRNA in the leukemia cells, but not in the colon cancer cells (75).”