Lipid metabolic reprogramming in cancer cells
By S. Beloribi-Djefaflia, S. Vasseur, F. Guillaumond. Oncogenesis, 2016
1,261 citations recorded by the source corpus.
Many human diseases, including metabolic, immune and central nervous system disorders, as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their pathways. This illustrates the fundamental role played by lipids in maintaining membrane homeostasis and normal function in healthy cells. We reviewed the major lipid dysfunctions occurring during tumor development, as determined using systems biology approaches. In it, we provide detailed insight into the essential roles exerted by specific lipids in mediating intracellular oncogenic signaling, endoplasmic reticulum stress and bidirectional crosstalk between cells of the tumor microenvironment and cancer cells. Finally, we summarize the advances in ongoing research aimed at exploiting the dependency of cancer cells on lipids to abolish tumor progression.
Subfields: Biochemistry, Cancer Research
View Paper: https://www.semanticscholar.org/paper/a404b1bdfea099175c6dbbdedfac2ed284b1a742
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biochemistry
In Cancer Research
Citations in the corpus
- Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues (2019, background): “Excessive lipids and cholesterol in cancer cells stored in lipid droplets are considered marks of cancer aggressiveness (reviewed in [156]).”
- Reprogramming of fatty acid metabolism in cancer (2019, background): “These include synthesis of biological membranes and the modulation of their fluidity, functioning as secondary messengers in signalling pathways to maintain homoeostasis, and serving as a form of energy storage in animals.(2) More than 100 years of research have provided tremendous insights into the”
- Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, positive): “Moreover, TAMs are also known to mediate immunosuppressive and metastasis-promoting functions in response to cancer cell/TAM-secreted lipid metabolites such as prostaglandin E2 (PGE2) and sphingosine-1-phosphate (S1P) [138][139][140].”