New concepts in the generation and functions of IgA

By O. Pabst. Nature reviews. Immunology, 2012

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The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. (2018, background): “Metabolites produced by bacteria may also affect local immunity via production of short-chain fatty acids (SCFAs), which, among a number of key activities, have been shown to augment immunity via IgA production by plasma cells (Pabst, 2012).”
Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model (2013, background): “We are also investigating other possible mechanisms that could prevent mucosal colonization; for example, a possible role for IgA and IgD which are secreted in primate lower and upper respiratory tracts, respectively (45, 46).”
Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease (2014, positive): “However, as compared to pathogen-induced IgA, commensal-induced IgA is generally believed to be of relatively low affinity and specificity (Pabst, 2012; Slack et al., 2012).”