Control of dopamine extracellular concentration in rat striatum by impulse flow and uptake.

By R. Wightman, Jayne B Zimmerman. 1990

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

The computational role of dopamine D1 receptors in working memory (2002, background): “…to the PFC originates from a small group of mesencephalic neurons (in the ventral tegmentum and substantia nigra) that projects to various cortical areas, flooding them with dopamine in a diffuse manner (Cass & Gerhardt, 1995; Garris, Collins, Jones, & Wightman, 1993; Wightman & Zimmerman, 1990).”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “In these regions, the half-life of DA is 75 ms or less (Wightman and Zimmerman, 1990; Garris et al., 1994), allowing DA to diffuse up to 12 mm from a release site (Gonon, 1997).”
Diffusion in Brain Extracellular Space (2008, unknown): “This situation is frequently represented by Michaelis-Menten kinetics and is exemplified by the behavior of dopamine in the ECS of the striatum (251, 413).”
Demon voltammetry and analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures (2011, methodology): “…Voltammetry, the current studies also compared the well-documented Michaelis-Menten parameters of [DA p ], V max , and K m (Wightman et al., 1988; Wightman and Zimmerman, 1990) to results obtained using analyses of tau, FWHH, half-life, T 20 , T 80 , slope, peak height, [DA c ], and AUC across…”
Solving the distal reward problem through linkage of STDP and dopamine signaling (2007, result): “In the simulations below, we take sd = 0.2 s, which is greater than the experimentally measured time constant of DA uptake in striatum (around 0.1 s, Wightman and Zimmerman 1990; Garris et al. 1994) but smaller than that in the prefrontal cortex (seconds, see Cass and Gerhardt 1995).”
Predictive reward signal of dopamine neurons. (1998, background): “The same effect is observed in nucleus accumbens (Wightman and Zimmerman 1990) and occurs even with Dopamine is released to 30–40% from synaptic and to 60–70% from extrasynaptic varicosities (Descarries et al.longer impulse intervals because of sparser reuptake sites (Garris et al. 1994b; Marshall…”