Inflammation in neurodegenerative diseases

By S. Amor, F. Puentes, D. Baker, P. Van Der Valk. Immunology, 2010

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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (2019, background): “These variants also induced glutamate excitotoxicity [268, 289] , thus increasing damage to neurons [310] and/or disturbing glutamate homeostasis [311] and thereby contributing to neuronal degeneration and hind-limb paralysis and possible demyelination [266] [267] [268] [269] .”
Role of neuroinflammation in neurodegenerative diseases (Review) (2016, neutral): “…to a Tc1/Th1-type immune response may contribute to a harmful brain inflammatory reaction, and the presence of antibodies against neuronal antigen observed in neurodegenerative diseases (some of them being pathogenic), solidify the involvement of the immune system in neurodegenerative diseases (5).”
Inflammation as a central mechanism in Alzheimer's disease (2018, background): “[73] Amor S, Puentes F, Baker D, van der Valk P.”
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Elevated levels of inflammatory cytokines are also observed in human multiple sclerosis [105].”
Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF (2015, background): “the other hand activation of TLRs can induce the expression of proinflammatory cytokines and chemokines, such as TNF, interleukins (IL), and CCL2 [85], which may contribute to disease progression [2] (Figure 2).”