A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised…

By T. Ngandu, J. Lehtisalo, A. Solomon, E. Levälahti, S. Ahtiluoto, R. Antikainen, Lars Bäckman, T. Hänninen, A. Jula, T. Laatikainen and 11 more. The Lancet, 2015

2,985 citations recorded by the source corpus.

Subfields: Physiology, Psychiatry and Mental health, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/a34a902f14a6986603003967f0077a810144c0a1

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Citations in the corpus

Brain metabolism in health, aging, and neurodegeneration (2017, positive): “The importance of exercise, diet, and intellectual and social stimulation in brain aging is emphasized by the results of a recent study showing that changes in diet, exercise, and cognitive training slow cognitive decline in elderly subjects (Ngandu et al, 2015).”
2016 Alzheimer's disease facts and figures (2016, positive): “Researchers have begun studying combinations of health factors (hypertension, for instance) and lifestyle behaviors (physical activity being an example) to learn whether combinations of risk factors better identify Alzheimer’s and dementia risk than individual risk factors [72].”
Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria (2016, methodology): “Among these studies, FINGER [148] is a landmark randomized controlled trial, which showed that a multicomponent approach targeting several vascular and lifestyle-related risk factors simultaneously in elderly people at risk of dementia can improve or maintain cognitive functioning.”
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “A combination of physical and cognitive training with control of nutritional and cardiovascular risk factors during a 2-year period led to improved cognitive performance in old adults at risk of developing dementia (Ngandu et al., 2015).”
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective (2015, positive): “Recent results from the study, which selected subjects with higher cardiovascular risk profiles, found overall cognitive performance as well as executive function improved significantly with a multi-component lifestyle intervention involving physical activity, nutritional guidance, cognitive trainin”
Alzheimer’s disease prevention: from risk factors to early intervention (2017, background): “To date, results from this large, long-term, randomized controlled trial (RCT) have demonstrated that a multidomain intervention including diet, exercise, cognitive training and monitoring vascular risk can improve or maintain cognitive functioning in older people (60–77 years old) from the general ”