Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

By S. Mi, X. Lee, Xiangping Li, G. Veldman, H. Finnerty, Lisa A. Racie, E. Lavallie, Xiang-Yang Tang, P. Edouard, Steve Howes and 2 more. Nature, 2000

1,622 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/a303889bf3a5ee07f63621001a9b1994568e9950

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In Immunology

In Pediatrics, Perinatology and Child Health

S. Baylin

Citations in the corpus

Origins, evolution, and phenotypic impact of new genes. (2010, neutral): “5; Mi et al. 2000; Dupressoir et al. 2009; Heidmann et al. 2009).”
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex (2004, methodology): “Rat brain, spinal cord and dorsal root ganglia frozen sections were prepared and processed as describe”
Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses (2015, positive): “…produce functional proteins including group-specific antigen (gag), polymerase (pol) with reverse transcriptase (RT), and the envelope (env) surface unit (SU) with a transmembrane immunosuppressive-like peptide (Mi et al., 2000; Blaise et al., 2005; de Parseval et al., 2003; Villesen et al., 2004).”
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation (2015, background): “The syncytin proteins, which are involved in placental development (28), are a well-known exception to this.”
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos (2016, neutral): “, 2011), ERVFRD-1 (rank 6) (Mi et al., 2000), GCM1 (rank 7) (Marchand et al.”
Mechanisms of membrane fusion: disparate players and common principles (2008, background): “Syncytins are expressed in the placenta and function in the trophoblast cell–cell fusion that results in syncytiotrophoblast formatio”
KRAB zinc finger proteins (2017, background): “…ERV-derived proteins can themselves be sources of genetic diversity, as illustrated in placental mammals in which formation of the syncytiotrophoblast, a placenta layer with extensive cellular fusion, is mediated by ERV envelopederived syncytins (Mi et al., 2000; Dupressoir et al., 2009, 2011).”