Next-generation probes, particles, and proteins for neural interfacing

By Jonathan Rivnay, Huiliang Wang, Lief Ericsson Fenno, Karl Deisseroth, George G. Malliaras. Science Advances, 2017

447 citations recorded by the source corpus.

Multimodal and multidisciplinary approaches lead to next-generation technologies for reading and modulating neural function. Bidirectional interfacing with the nervous system enables neuroscience research, diagnosis, and therapy. This two-way communication allows us to monitor the state of the brain and its composite networks and cells as well as to influence them to treat disease or repair/restore sensory or motor function. To provide the most stable and effective interface, the tools of the trade must bridge the soft, ion-rich, and evolving nature of neural tissue with the largely rigid, static realm of microelectronics and medical instruments that allow for readout, analysis, and/or control. In this Review, we describe how the understanding of neural signaling and material-tissue interactions has fueled the expansion of the available tool set. New probe architectures and materials, nanoparticles, dyes, and designer genetically encoded proteins push the limits of recording and stimulation lifetime, localization, and specificity, blurring the boundary between living tissue and engineered tools. Understanding these approaches, their modality, and the role of cross-disciplinary development will support new neurotherapies and prostheses and provide neuroscientists and neurologists with unprecedented access to the brain.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/39e8a8d75d6bb3089f0b224ff49a8767fab5ffbe

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In Biomedical Engineering

In Cellular and Molecular Neuroscience

Citations in the corpus

Organic electronics for neuromorphic computing (2018, background): “Additional development could further enhance the connection between synaptic memristive arrays and adaptive control of physiology and processes of cells, tissue and organs; and vice versa to enhance site-specific sensing and monitoring 106,110 .”
Challenges and opportunities for large-scale electrophysiology with Neuropixels probes (2018, background): “Research into materials and designs for such applications is ongoing [62,63] but largely parallel to the development of CMOS probes like Neuropixels due to the incompatibility of most of those materials with the high-density CMOS manufacturing methods.”