Alternative splicing as a regulator of development and tissue identity

By Francisco E. Baralle, Jimena Giudice. Nature reviews. Molecular cell biology, 2017

1,172 citations recorded by the source corpus.

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a2d3947fba4ed83b3f7a53aa193c07d622aca854

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In Molecular Biology

1. Benjamin J. Blencowe
2. Ying Yang
3. Yun-Gui Yang
4. Phillip J Hsu
5. Jernej Ule
6. Yu-Sheng Chen

Citations in the corpus

• Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, background): “In addition to RNA-protein interactions, RNA-RNA base pairing, chromatin modifications, small RNAs, and RNA polymerase II complex have also been reported to regulate alternative splicing patterns.(128,130) Recently, several lines of evidence indicated that m(6)A also serves as an important pre-mRNA ”
• Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution. (2019, background): “To date, dynamic alternative splicing networks have been detected in embryonic stem and precursor cells, during the differentiation or reprogramming of various cell lineages as well as epithelial-mesenchymal transitions, and in adult organs such as the brain, heart, skeletal muscle, liver, kidney, a”