Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas

By R. Santos, A. C. S. e Silva, C. Maric, Denise M. R. Silva, Raquel P. Machado, I. de Buhr, S. Heringer-walther, S. V. Pinheiro, M. T. Lopes, M. Bader and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,752 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a2d0e2f7cdd0fc00bbb884f0463fa24429dca260

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In Cardiology and Cardiovascular Medicine

In Cellular and Molecular Neuroscience

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Citations in the corpus

SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways (2020, background): “ACE2 also hydrolyses Ang II to generate Ang-(1-7), which binds to the G-protein coupled receptor MAS (Reudelhuber 2005; Santos et al.”
The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease (2007, background): “It has been suggested that Ang 1-7 acts on its own receptor, postulated to be the orphan heterotrimeric guanine nucleotide-binding protein-coupled receptor, MAS receptor (Santos et al., 2003).”
Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis (2020, background): “The main role of ACE2 is to incise Ang II to generate Ang 1-7, which mediates the protective effects of vasodilation, anti-inflammatory and anti-proliferation, to antagonize Ang II-induced vascular smooth muscle contraction, cell proliferation, fibrosis promotion and vascular inflammation [21] [22] ”
Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics (2020, background): “By contract, ACE2 inactivates angiotensin II while generating angiotensin 1–7, a heptapeptide having a potent vasodilator function via activation of its Mas receptor (Santos et al., 2003), and thus serving as a negative regulator of the renin–angiotensin system.”
Hypertension Renin–Angiotensin–Aldosterone System Alterations (2015, background): “ACE2-Ang-(1–7)-Mas receptor Axis Ang-(1–7), mainly produced from Ang II by ACE2 (Figure 1), opposes AT 1 receptor-mediated effects via its binding to the Mas receptor.(141) Yet, it also binds AT 2 receptors and, at high concentrations, even acts as a partial AT 1 receptor agonist.”
Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure (2016, background): “Ang 1–7 activates MasR and exert various effects, the majority of which antagonize Ang II’s effects.(15,20) These effects”