Signal transduction and endocytosis: close encounters of many kinds

By A. Sorkin, M. von Zastrow. Nature reviews. Molecular cell biology, 2002

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Cell-signalling dynamics in time and space (2006, background): “Qualitatively different patterns of signalling are generated by receptors and downstream effectors that are associated with endosomes or the plasma membrane 81 .”
Subcellular targeting strategies for drug design and delivery (2010, background): “Contrary to the previously accepted tenet that endocytosis downregulates signalling, recent work suggests that endosomes contain signalling-active molecules that ultimately lead to nuclear signallin”
Multivesicular Endosome Biogenesis in the Absence of ESCRTs (2009, background): “Cell-surface receptor endocytosis is an important mechanism for controlling receptor signalling and is therefore thought to play a role in preventing carcinogenesis (6,7).”
Ras proteins: different signals from different locations (2003, background): “This has been the subject of a recent detailed revie”