Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease
By S. Iyer, Genhong Cheng. Critical Reviews in Immunology, 2012
1,354 citations recorded by the source corpus.
Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases. Thus a fundamental understanding of IL-10 gene expression is critical for our comprehension of disease progression and resolution of host inflammatory response. In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/6808105ae82a33dc429ad08bf21619b04210ecdb
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Citations in the corpus
- Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies (2014, background): “IL-10, primarily produced by monocytes/ macrophages, regulates both innate and cell-mediated immunity by inhibiting activated macrophages.(23) IL-10 can also be produced by mast cells, B cells, regulatory T cells, and helper T cells (TH2), but not commonly by cytotoxic T lymphocytes.”
- CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. (2015, background): “IL-10 is a negative regulator of macrophage function that is markedly elevated in a number of inflammatory conditions, including MAS/HLH.(61) IL-10 is not commonly produced by cytotoxic T cells, but is produced by monocytes/macrophages, B cells, mast cells, helper T cells (TH2), and regulatory T cel”