Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

By Amay J. Bandodkar, P. Gutruf, Jungil Choi, KunHyuck Lee, Yurina Sekine, J. Reeder, W. Jeang, A. Aranyosi, Stephen P. Lee, Jeffrey B. Model and 12 more. Science Advances, 2019

636 citations recorded by the source corpus.

Battery-free, wireless microfluidic/electronic system for multiparameter sweat analysis. Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.

Subfields: Bioengineering, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/a23191f1f54fa21d7857f185a701a58bec8832e2

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In Bioengineering

  1. Wei Gao
  2. Yiran Yang

In Biomedical Engineering

  1. Yiran Yang
  2. Wei Gao
  3. Yu Song
  4. Jihong Min
  5. Aaron D. Ames
  6. Avik De

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