DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells.

By S. Jahr, H. Hentze, S. Englisch, D. Hardt, F. O. Fackelmayer, R. Hesch, R. Knippers. Cancer Research, 2001

2,258 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a2146e11d802179cf3ff632c7bfdad088a34365b

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1. Mitchell R. McGill
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Citations in the corpus

• Liquid Biopsies: Genotyping Circulating Tumor DNA (2014, background): “When the length of cfDNA strands are measured, they often assume the classic ladder pattern in integer multiples of 180 base pairs,(57) characteristic of the apoptotic process.(55,58,59) In fact, most cfDNA fragments measure between 180 and 200 base pairs, suggesting that apoptosis likely produces t”
• OXIDANT STRESS, MITOCHONDRIA AND CELL DEATH MECHANISMS IN DRUG-INDUCED LIVER INJURY: LESSONS LEARNED FROM ACETAMINOPHEN HEPATOTOXICITY (2012, background): “Regarding the mechanisms of DNase1-induced cell death, it was hypothesized that the DNA damage induced by DNase1 may lead to the activation of repair mechanisms, including poly(adenosine diphosphate-ribose) polymerase-1 (PARP-1) (Napirei et al., 2006).”
• COVID-19 update: Covid-19-associated coagulopathy (2020, background): “By contrast, cf-DNA released in the setting of infection is the result of cellular and tissue necrosis, apoptosis, autophagy or mitotic catastrophe [38] (Fig.”
• Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. (2011, result): “31,32 The effect of histones was entirely platelet dependent, as shown by the following observations: (1) histones failed to induce detectable thrombin formation in CTI-inhibited PPP even in the presence of an exogenous procoagulant surface, indicating that they are not able to trigger thrombin gene”
• Origins, structures, and functions of circulating DNA in oncology (2016, background): “Apoptotic DNA cleavage produces a characteristic ladder pattern of 180–200 bp or multiples thereof (oligonucleosomes) of DNA fragmentation [108].”
• Fragment Length of Circulating Tumor DNA (2016, background): “The overall distribution of fragment lengths identified for ctDNA and cell-free DNA in our study was consistent with cellular apoptosis rather than necrosis [25].”
• Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood (2008, result): “These findings suggest that the majority of cell-free DNA in the plasma is derived from apoptotic cells, in accordance with previous findings (22, 23, 25, 26).”