Androgen-Independent Prostate Cancer Is a Heterogeneous Group of Diseases

By R. Shah, R. Mehra, Arul M. Chinnaiyan, Ronglai Shen, Debashis Ghosh, Ming Zhou, G. MacVicar, Soorynarayana Varambally, Jason Harwood, T. Bismar and 3 more. Cancer Research, 2004

646 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/a1eda9d064b14ecd4ae500b8620b3ae42c6b0d9b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Arul M. Chinnaiyan
2. Mauno Vihinen
3. Debashis Ghosh
4. Daniel R. Rhodes
5. C. Abate-Shen
6. Mark A. Rubin
7. Trevor M. Penning
8. M. Shen

In Oncology

1. C. Abate-Shen
2. M. Shen
3. J. Joyce
4. J. Massagué
5. A. Ostman
6. K. Pietras

In Pulmonary and Respiratory Medicine

1. Arul M. Chinnaiyan
2. Mark A. Rubin
3. Celestia S. Higano
4. R. Vessella

Citations in the corpus

• Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling (2017, background): “Although initially highly effective as a treatment for metastatic PC, ADT is characterized by the predictable emergence of resistance, a disease state termed castration-resistant prostate cancer (CRPC).”
• Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. (2006, methodology): “Immunohistochemistry. Tissue microarrays containing primary prostate cancer and metastatic androgen-independent prostate cancer from warm autopsies were prepared as described, and additional androgenindependent prostate cancer samples were obtained from transurethral prostate resections in patients ”
• Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. (2005, background): “and hormone-refractory metastatic tissues (Shah et al., 2004).”
• Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. (2008, result): “Castration-resistant tumors generally showed intense nuclear staining for AR, as well as strong cytoplasmic PSA reactivity (Fig. 1A), although heterogeneity in expression was found in a subset of tumors as we and others have previously described (11, 18 ).”
• Copy Number Analysis Indicates Monoclonal Origin of Lethal Metastatic Prostate Cancer (2009, positive): “These findings, together with transcript and protein expression studies in a similar set of subject”
• Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “However, expression levels of AR are heterogeneous and even absent in some metastases (Shah et al., 2004).”
• Molecular genetics of prostate cancer: new prospects for old challenges. (2010, background): “However, transgenic mice that overexpress SV40 large T antigen typically have short latency, and develop cancer with features of neuroendocrine differentiation (Kaplan-Lefko et al. 2003; Shappell et al. 2004).”