Characterization of the expression of MHC proteins in human embryonic stem cells

By Micha Drukker, Gil Katz, A. Urbach, Maya Schuldiner, G. Markel, J. Itskovitz‐Eldor, B. Reubinoff, O. Mandelboim, N. Benvenisty. Proceedings of the National Academy of Sciences of the United States of America, 2002

692 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/a1a7faa453b4be529248fdab0150d347bd17b840

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Citations in the corpus

• Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs (2010, result): “Finally, fluorescence-activated cell sorter (FACS) analysis showed that hESCs andmEpiSCs had initiated surface expression of MHC class I proteins, which are normally expressed on somatic cells (34), in contrast to mESCs and naïve hESCs/hiPSCs, which had residual surface expression consistent with a ”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “Although the levels of MHC-I expression on hES cells are low, they increase moderately after differentiation either in vitro or in vivo, and markedly following interferon treatment (101).”
• Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, background): “ESCs express few class I major histocompatibility antigens and have virtually no expression of class II molecules (Drukker et al., 2002; Nussbaum et al., 2007; Swijnenburg et al., 2005), which initially raised hopes that ESC derivatives might not induce an immune response when transplanted.”