A molecular programme for the specification of germ cell fate in mice

By M. Saitou, S. Barton, M. Surani. Nature, 2002

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PGC7/Stella protects against DNA demethylation in early embryogenesis (2007, background): “PGC7/Stella was initially identified as a gene predominantly expressed in primordial germ cells (PGCs), based on a comparison of gene expression in PGCs and embryonic stem (ES) cells, and in single nascent germ cells and their somatic neighbor”
Mechanisms of germ cell specification across the metazoans: epigenesis and preformation (2003, background): “5873Review signals, which direct them to differentiate into PGCs (Saitou et al., 2002).”
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. (2011, positive): “Thus, the gene expression dynamics associated with PGCLC induction are very similar to those associated with PGC specification (Kurimoto et al., 2008; Saitou et al., 2002).”
Oocyte formation by mitotically-active germ cells purified from ovaries of reproductive age women (2012, background): “2c,d ), as well as matched gene expression profiles rich in markers for early germ cell”
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. (2006, neutral): “described (Saitou et al. 2002).”
The mammalian ovary from genesis to revelation. (2009, background): “well as the further differentiation of the PGC (21).”