YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA

By Hailing Shi, Xiao Wang, Zhike Lu, B. Zhao, Honghui Ma, Phillip J Hsu, Chang Liu, Chuan He. Cell Research, 2017

1,613 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a178803d4779f3d83a6b1d8aef932248184a4dda

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In Molecular Biology

Citations in the corpus

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification (2017, background): “YT521-B homology domain family (YTH) proteins are the first characterized readers of m6A, which regulate mRNA stability and translation (Shi et al., 2017; Wang et al., 2015).”
Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers (2019, background): “By contrast, the other two cytoplasmic m6A readers, YTHDF1 and YTHDF3, are suggested to promote translation of target transcripts in HeLa cells by recruiting translation initiation factors (Shi et al., 2017; Wang et al., 2015).”
RNA N6-methyladenosine modification in cancers: current status and perspectives (2018, background): “Of them, YTHDF2, YTHDF3, and YTHDC2 promote decay of m(6)A-modified mRNAs.(18,20,23) Interestingly, in”
Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection (2020, background): “Other than promoting mRNA translation, the YTHDF2-m6A-mRNA complex has been reported to control mRNA degradation [26], and YTHDF3 has been found to accelerate mRNA decay via cooperation with YTHDF2 [72].”
Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia (2019, background): “The m6A reader proteins, YTHDF1/2/3, YTHDC1/2, and IGF2BP1/2/3, preferentially recognize m6A in mRNA (Dominissini et al., 2012; Hsu et al., 2017; Huang et al., 2018; Li et al., 2017a; Roundtree et al., 2017b; Shi et al., 2017; Wang et al., 2014a; Xiao et al., 2016).”
Functions of N6-methyladenosine and its role in cancer (2019, background): “YTHDF3 enhances translation and degradation by interacting with YTHDF1 and YTHDF2 [33, 34] He et al.”
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, background): “Transcripts with enhanced 5’UTR methylation are selectively translated via a cap-independent mechanism.29 YTHDF3, together with YTHDF1, regulates mRNA translation by interacting with a common set of ribosomal proteins.26,27 In addition, YTHDF3 could also mediate mRNA decay by directly interacting wi”
Methylation multiplicity and its clinical values in cancer (2021, positive): “YTHDF3 could interact with YTHDF1 or YTHDF2 to enhance its ability in enhancing translation and mediating protein decay (Refs 36, 37).”