Structural dynamics of dendritic spines in memory and cognition.

By Haruo Kasai, M. Fukuda, Satoshi Watanabe, Akiko Hayashi-Takagi, J. Noguchi. 2010

819 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

NISPA: Neuro-Inspired Stability-Plasticity Adaptation for Continual Learning in Sparse Networks (2022, background): “While the underlying mechanisms are not fully understood yet, recent studies have shown that synapse rewiring occurs rapidly during learning (Fu & Zuo, 2011; Kasai et al., 2010; Deger et al., 2012).”
Labelling and optical erasure of synaptic memory traces in the motor cortex (2015, background): “(5) Increased stability of AS-PaRac1 in the PSD: it is likely that the stability of the PSD-integrated AS-PaRac1 increase, as does the typical PSD scaffold proteins47.”
Dendritic spine pathology in neuropsychiatric disorders (2011, background): “At the cellular level, spine structural plasticity is tightly coordinated with synaptic function and plasticity; for example, spine enlargement parallels long-term potentiation, whereas long-term depression is associated with spine shrinkag”
Spike-Timing Dependence of Structural Plasticity Explains Cooperative Synapse Formation in the Neocortex (2012, background): “CaMKII has also been shown to be necessary for structural and long-term plasticity [52,53,4], and may also drive presynaptic changes [54].”
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012, background): “Insertion of additional receptors therefore is likely to affect the ultrastructure of the synapse, and in fact, spines associated with synapses that underwent LTP enlarge (Matsuzaki et al. 2004; Harvey and Svoboda 2007; Holtmaat and Svoboda 2009; Kasai et al. 2010).”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, neutral): “Synaptic stimulation under conditions that induce LTP of excitatory synapses is also associated with sustained structural alterations in the postsynaptic region, including an increase in the number of dendritic spines and their volume (Kasai et al., 2010).”
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy (2012, background): “This is perhaps not surprising, as both deficient and excessive LTP, LTD, 'plasticity gene' activity, neurogenesis and dendritic spine generation have a deleterious effect on cognitive processin”
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens (2010, background): “As thin spines are thought to represent highly plastic, newly formed spines that lack AMPA receptors, we speculate that cocaine-induced DNA methylation generates such less-responsive thin spine”
Learning rules and persistence of dendritic spines (2010, background): “Plasticity and the spontaneous generation, selection and strengthening of dendritic spines Together, the fifteen rules suggest a new mechanism for the creation and strengthening of neuronal circuits in the cerebral cortex (Morita et al., 2009; Kasai et al., 2010), as explained below.”
Synapses and memory storage. (2012, background): “Such changes can involve alterations in morphology of preexisting synapses, including the enlargement of dendritic spines (the sites of a pyramidal neuron’s excitatory input) during LTP and spine shrinkage during LTD (Kasai et al. 2010).”
Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. (2018, neutral): “Considerable evidence supports the existence of active maintenance mechanisms for working memory lasting for seconds (Miller and Cohen, 2001; Palva and Palva, 2007) and long-term memory lasting for days (Bailey et al., 2004; Kandel et al., 2014; Kasai et al., 2010; Sacktor, 2011).”
The Biology of Forgetting – A Perspective (2017, background): “…that, unlike the active forgetting due to retroactive interference that potentially disrupts consolidation described above, the brain also has the inherent biological capacity to erode memory traces using signaling systems like those used for acquisition and consolidation (Kasai et al., 2010).”
The synaptic plasticity and memory hypothesis: encoding, storage and persistence (2014, background): “Recent reviews of the persistence of LTP/LTD collectively point to the importance of translational control of dendritic mRNAs, and that spine dynamics may be remarkably fast to be in register with the relatively immediate functional changes [9–11].”