Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases.
By Benjamin J. Blencowe. TIBS -Trends in Biochemical Sciences. Regular ed, 2000
730 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a14da5ddb7d85b8cd311eb94bbeaba8b7356951e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- Adrian R. Krainer
- Luca Cartegni
- Tal Pupko
- Xiang H. F. Zhang
- L. Chasin
- Brenton R. Graveley
- N. Faustino
- T. Cooper
In Molecular Biology
- T. Cooper
- Xiang H. F. Zhang
- L. Chasin
- Adrian R. Krainer
- Luca Cartegni
- N. Faustino
- Amir Goren
- Gil Ast
Citations in the corpus
- Sorting out the complexity of SR protein functions. (2000, background): “related reviews recently published elsewhere (Tacke & Manley, 1999; Blencowe, 2000)+)”
- Computational definition of sequence motifs governing constitutive exon splicing. (2004, background): “The additional information needed to distinguish true from false exons is thought to reside in splicing enhancer and splicing silencer sequence elements (Blencowe 2000; Wagner and GarciaBlanco 2001; Cartegni et al. 2002; Ladd and Cooper 2002).”
- Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1 (2002, background): “Found in both constitutive and alternative exons, ESEs are cis -acting elements that function as binding sites for serine/arginine-rich (SR) proteins, a family of essential splicing factors that are also involved in alternative splicing regulatio”
- A construct with fluorescent indicators for conditional expression of miRNA (2008, neutral): “A synthetic artificial intron (Figure 2A) was designed to contain typical intron splicing regulatory elements [50-52].”
- Pre-mRNA splicing and human disease. (2003, background): “1B; Blencowe 2000).”
- Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. (2006, background): “These motifs are classified as exonic or intronic splicing enhancers (ESE/ISE) and silencers (ESS/ISS), and they are required for the regulation of both constitutive and alternative splicing (Blencowe, 2000; Graveley, 2000).”