Neutrophils scan for activated platelets to initiate inflammation
By Vinatha Sreeramkumar, J. M. Adrover, I. Ballesteros, M. Cuartero, J. Rossaint, I. Bilbao, M. Nácher, Christophe Pitaval, Irena Radovanovic, Y. Fukui and 7 more. Science, 2014
621 citations recorded by the source corpus.
Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils’ bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds. Blood neutrophil cells sample platelets in the bloodstream before infiltrating surrounding tissue. A two-cell collaboration for inflammation Immune cells called neutrophils are first responders to infection. Neutrophils move within and through blood vessels to get to sites of infection quickly. Sreeramkumar et al. found that mouse neutrophils rely on platelets to help find such sites. Neutrophils extended protrusions into blood vessels. When these protrusions came into contact with platelets, the neutrophils migrated into the surrounding tissue to carry out their inflammatory functions. Preventing these neutrophilplatelet interactions alleviated collateral inflammatory damage to tissues in several injury models in mice. Science, this issue p. 1234
Subfields: Immunology, Immunology and Allergy
View Paper: https://www.semanticscholar.org/paper/a12d191cef11df38f67fc64afde8f73368e9285e
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In Immunology
Citations in the corpus
- RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics (2015, neutral): “…(Calverley et al., 2010; Nilsson et al., 2011), whereas platelets do also directly interact with tumor cells (Labelle et al., 2011), neutrophils (Sreeramkumar et al., 2014), circulating NK-cells (Palumbo et al., 2005; Placke et al., 2012), and circulating tumor cells (Ting et al., 2014; Yu et…”
- Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility (2018, background): “P-selectin glycoprotein ligand-1 (PSGL-1) expressed on leukocytes can interact with P-selectin and lead to the activation of neutrophils (Sreeramkumar et al., 2014).”
- Specification of tissue-resident macrophages during organogenesis (2016, methodology): “To determine the CD31+ area in Id3+/− and Id3−/− liver sections, maximum intensity Z-projections pictures were converted into binary images and the CD31+ area was measured using Image J (NIH, Bethesda, MD, USA) (39).”