Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation

By Rienk Nieuwland, A. Böing, F. Romijn, C. Hack, A. Sturk, R. Berckmans. Thrombosis and Haemostasis, 2001

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Inflammation, endothelium, and coagulation in sepsis (2008, methodology): “For example, in plasma from fresh blood of healthy individuals, MPs originating from platelets, granulocutes, erythrocytes, and ECs were identified by using flow cytometry [28, 29].”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “In addition, blood from healthy subjects contains cell-derived vesicles, but these vesicles do not expose coagulant TF and are associated with an anticoagulant rather than procoagulant function (Tans et al., 1991; Dahlbäck et al., 1992; Berckmans et al., 2001).”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “This may suggest that EVs mainly execute an anticoagulant role, as the low amount of thrombin induced by EVs activates protein C that, in turn, inactivates Factor Va (364).”