Detecting recent positive selection in the human genome from haplotype structure

By Pardis C Sabeti, David Reich, J. Higgins, Haninah Levine, D. Richter, S. Schaffner, Stacey Gabriel, J. Platko, Nick Patterson, G. McDonald and 7 more. Nature, 2002

2,041 citations recorded by the source corpus.

Subfields: Genetics

View Paper: https://www.semanticscholar.org/paper/a060494fdb687f13c644dfc2b5bc1468b2bacc21

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In Genetics

Citations in the corpus

Applications of next-generation sequencing to the study of biological invasions (2015, background): “Genome-wide coverage using NGS allows the detection of processes affecting more than one locus, like genomic regions that show evidence of selective sweeps (Sabeti et al., 2002; Schlötterer, 2003; Boitard et al., 2012).”
How malaria has affected the human genome and what human genetics can teach us about malaria. (2005, background): “For example, some strains of mice are resistant to nonlethal strains but highly susceptible to lethal strains of Plasmodium yoelii, whereas other mouse strains show the opposite pattern (Sayles and Wassom 1988).”
Probability Models for DNA Sequence Evolution (2002, background): “Sagitov (1999) and Möhle and Sagitov (2001) obtained a definitive solution to this problem.”
Detecting loci under selection in a hierarchically structured population (2009, background): “Slatkin and Voelm (1991) have called this particular population structure a hierarchical island model and have derived relationships between Nei’s G statistics (Nei, 1973) and migration rates within and between groups.”
Signals of recent positive selection in a worldwide sample of human populations. (2009, background): “These types of evidence include haplotype structure (Hudson et al. 1994; Sabeti et al. 2002), linkage disequilibrium (Kim and Nielsen 2004; Jensen et al. 2007), the allele frequency spectrum (Smith and Haigh 1974; Tajima 1989), and population differentiation (Lewontin and Krakauer 1973).”
Balancing Selection and Its Effects on Sequences in Nearby Genome Regions (2006, background): “creates a high frequency of one haplotype [53,56].”
Genetic signatures of strong recent positive selection at the lactase gene. (2004, methodology): “However, the mere presence of a long haplotype, although consistent with selection, does not by itself constitute a signature of a selective event (Sabeti et al. 2002).”
Search for nucleotide diversity patterns of local adaptation in dehydrins and other cold-related candidate genes in Scots pine (Pinus sylvestris L.) (2008, background): “Increase in frequency of such alleles may also result in higher linkage disequilibrium (Sabeti et al. 2002).”
selscan: An Efficient Multithreaded Program to Perform EHH-Based Scans for Positive Selection (2014, background): “Extended Haplotype Homozygosity (EHH) (Sabeti et al. , 2002), Integrated Haplotype Score (iHS) (Voight et al. , 2006), and Cross-population Extended Haplotype Homozygosity (XPEHH) (Sabeti et al. , 2007) are statistics designed to identify putative regions of recent or ongoing positive selection in…”
A Map of Recent Positive Selection in the Human Genome (2006, background): “Alcohol dehydrogenase cluster in east Asians, carbohydrate metabolism genes like mannose in Yoruba and sucrose and lactose in the Europeans.”