The cardiac fibroblast: therapeutic target in myocardial remodeling and failure.

By R. D. Brown, S. K. Ambler, M. Mitchell, C. Long. Annual Review of Pharmacology and Toxicology, 2005

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Formation and function of the myofibroblast during tissue repair. (2007, background): “Myofibroblast-generated contractures are also characteristic for fibrosis affecting vital organs such as the liver (Desmouliere et al., 2003), heart (Virag and Murry, 2003; Brown et al., 2005), lung (Phan, 2002; Thannickal et al., 2004), and kidney (Lan, 2003).”
Cardiac fibrosis. (2020, background): “Resident cardiac fibroblasts may serve to maintain the structural integrity of the matrix network,(16) regulating collagen turnover, a process that requires ongoing synthesis and degradation of ECM proteins.(17,18) Fibroblast-specific baseline activation of Smad3 signal-”
The Pathogenesis of Cardiac Fibrosis (2013, neutral): “Homeostatic control of the cardiac extracellular matrix involves ongoing synthesis and degradation of matrix proteins [17, 18].”