New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

By M. Knetsch, L. Koole. 2011

682 citations recorded by the source corpus.

Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on

Subfields: Materials Chemistry

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Citations in the corpus

Electrochemical synthesis, characterisation and phytogenic properties of silver nanoparticles (2015, background): “…nanoparticles of silver have been gaining much attention and being used in almost every field, including medicine (Nithya and Ragunathan 2014; Knetsch and Koole 2011), catalysis (Venkatesham et al. 2012), bio sensing (Priyanka et al. 2013; Doria et al. 2012; Zhu et al. 2009), drug delivery…”
Nanotechnology as a therapeutic tool to combat microbial resistance. (2013, background): “2) At sufficiently high concentrations, free Cu++ ions induce formation of reactive oxygen species (ROS), which inhibit both DNA replication and amino acid synthesis in microbes [6].”
A review on the wettability of dental implant surfaces II: Biological and clinical aspects. (2014, background): “These strategies include surface coatings with dendrimers or polymeric brushes such as poly(ethylene glycol) layers [105, 106], surface modifications using positively charged molecules or zwitterionic coatings such as phosphorylcholine [107, 108], as well as surface application of silver nanoparticl”
Graphene oxide functionalized with ethylenediamine triacetic acid for heavy metal adsorption and anti-microbial applications (2014, background): “[13] Knetsch MLW, Koole LH.”
A Shape‐Adaptive, Antibacterial‐Coating of Immobilized Quaternary‐Ammonium Compounds Tethered on Hyperbranched Polyurea and its Mechanism of Action (2014, background): “QACs are also stable in the human body, poorly metabolized and mainly excreted in non-metabolized form.([22]) QACs can be hemolytic when not immobilized on a surface and environmentally toxic.”
The antimicrobial activity of nanoparticles: present situation and prospects for the future (2017, background): “The mechanisms of resistance include expression of enzymes that modify or degrade antibiotics, such as β-lactamases and aminoglycosides,(2) modification of cell components, such as the cell wall in vancomycin resistance and ribosomes in tetracycline resistance,(3) and expression of efflux pumps, whi”