The antimicrobial activity of nanoparticles: present situation and prospects for the future
By Linlin Wang, Chen Hu, L. Shao. International Journal of Nanomedicine, 2017
2,944 citations recorded by the source corpus.
Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed.
Subfields: Materials Chemistry, Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/ed62aef4927f90f6138b79fda3622a58817c03cf
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In Materials Chemistry
Citations in the corpus
- Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications (2021, background): “Among M-NPs with identical surface-to-volume ratios, the shape plays an equally important role, where nanotubes and rods are more effective due to the exposition of their planes and thus oxidation of the metals [3,27,28].”
- Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties (2018, background): “In addition, interaction of NPs with the cell enhances the expression of the genes responsible for the formation of lysosomes [50], disturbs their functioning [51], and inhibits protein synthesis [52, 53].”
- Treatment Strategies for Infected Wounds (2018, background): “In addition, NPs can also penetrate the cell wall, affect metabolic paths, disrupt mitochondria and can also affect proton efflux pumps subsequent with a pH modification and a membrane’s surface charge disorder [146,149].”