RIM1α is required for presynaptic long-term potentiation

By P. Castillo, S. Schoch, F. Schmitz, T. Sūdhof, R. Malenka. Nature, 2002

270 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/a020f6b35080cef4ffc6722c6ad74a705d85373f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. T. Sūdhof
2. S. Seino
3. T. Shibasaki
4. R. Malenka
5. S. Harrison

In Cellular and Molecular Neuroscience

1. R. Malenka
2. J. Kauer
3. T. Sūdhof
4. P. Castillo
5. S. Seino
6. Vivien Chevaleyre
7. T. Shibasaki
8. A. Kreitzer

In Genetics

1. Michael C. Schatz
2. Richard K. Wilson
3. Elaine R. Mardis
4. R. Malenka
5. T. Sūdhof
6. Jerzy K. Kulski
7. Piotr Fryzlewicz
8. Mustafa Sahin

Citations in the corpus

• De Novo Gene Disruptions in Children on the Autistic Spectrum (2012, background): “Among these were RIMS1, a Ras superfamily member necessary for presynaptic long-term potentiation (Castillo et al., 2002).”
• Synaptic plasticity and addiction (2007, background): “Rab3A and RIM1α, proteins that act to coordinate synaptic vesicle interactions with the presynaptic active zone, have an essential role in the increased glutamate releas”
• PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Rim1 knockout mice exhibit an altered short-term synaptic plasticity and an absence of LTP in mossy fiber synapses in the hippocampus (92).”
• Rab‐αGDI activity is regulated by a Hsp90 chaperone complex (2002, background): “…and consistent with our evidence, a second possibility is that by interfering with the cycling of aGDI through the Hsp90-containing chaperone complex, a Rab3A-containing priming complex (Castillo et al., 2002; Schoch et al., 2002) is unable to ef®ciently mature in response to Rab3A hydrolysis.”
• RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone (2002, result): “We also examined LTP, which was induced normally in the CA1 region of the RIM1α knockout mice ( Supplementary Information ), suggesting that in contrast to mossy fibre LT”
• Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release (2006, methodology): “Vibratome-cut transverse hippocampal slices (400-mm thick) from 3- to 5-week-old mice were used for field recordings using standard procedures (Castillo et al, 2002; Schoch et al, 2002).”