RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

By S. Schoch, P. Castillo, Tobias Jo, K. Mukherjee, M. Geppert, Yun Wang, F. Schmitz, R. Malenka, T. Sūdhof. Nature, 2002

638 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ce6472682a48ceff63ceb8f9b84e8d0288e910fe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Molecular Biology

Citations in the corpus

PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Rim1 plays an important role as a scaffold protein in integrating both active zone proteins and synaptic vesicles into the sites of neurotransmitter release (483).”
Insulin granule dynamics in pancreatic beta cells (2003, background): “RIM interacts with a plethora of proteins and seems to function as a protein scaffold [63, 64].”
Interaction between Liprin-α and GIT1 Is Required for AMPA Receptor Targeting (2003, background): “Liprin- directly associates with RIM, an active zone component that regulates neurotransmitter release (Schoch et al., 2002).”
Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release (2006, methodology): “Vibratome-cut transverse hippocampal slices (400-mm thick) from 3- to 5-week-old mice were used for field recordings using standard procedures (Castillo et al, 2002; Schoch et al, 2002).”
The synaptic vesicle cycle. (2004, positive): “…et al. 1997a, 2000; Betz et al. 2001; Wang et al. 2001b; Schoch et al. 2002); (b) a central PDZ domain that binds the C-terminus of ERCs (Ohtsuka et al. 2002, Wang et al. 2002); and (c) two C-terminal C 2 domains, of which the second, so-called C 2 B domain binds to α-liprins (Schoch et al. 2002).”
De Novo Gene Disruptions in Children on the Autistic Spectrum (2012, background): “A targeted Rims1 mutation in the mouse leads to increased postsynaptic density and impaired associative learning as well as memory and cognition deficits (Powell et al., 2004; Schoch et al., 2002), and the frame shift allele we found may lead to a similarly severe condition.”
SNAREs and traffic. (2005, background): “The tethering of synaptic vesicles is regulated by Rab3 and its effector RIM1 [19,100].”
Rab‐αGDI activity is regulated by a Hsp90 chaperone complex (2002, background): “Alternatively, and consistent with our evidence, a second possibility is that by interfering with the cycling of aGDI through the Hsp90-containing chaperone complex, a Rab3A-containing priming complex (Castillo et al., 2002; Schoch et al., 2002) is unable to ef®ciently mature in response to Rab3A hy”
LAR, liprin α and the regulation of active zone morphogenesis (2007, background): “Liprin , presumably via interactions with RIM1 and ERC, partly colocalizes with piccolo clusters at the active zone (Ko et al., 2003a).”