Control of Excitatory and Inhibitory Synapse Formation by Neuroligins

By Ben Chih, H. Engelman, P. Scheiffele. Science, 2005

722 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/9fffd7c4d1e0b5d0e3a2ac1a62a5cba7f4d15beb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. T. Sūdhof
2. B. Barres
3. Ann Marie Craig
4. Yunhee Kang
5. O. Marín
6. Weiqi Zhang
7. F. Varoqueaux
8. Randi L. Rawson

In Developmental Neuroscience

1. B. Barres
2. O. Marín
3. Ann Marie Craig
4. T. Sūdhof
5. C. Eroglu
6. M. Sofroniew
7. N. J. Allen

In Neurology

1. B. Barres
2. T. Sūdhof
3. O. Marín
4. C. Eroglu
5. M. Sofroniew
6. N. J. Allen
7. M. Pekny

Citations in the corpus

• Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. (2005, background): “The transmembrane neuronal proteins neuroligin and neurexin constitute an important part of the intrinsic synaptic machinery (reviewed in Scheiffele [2003]; Chih et al. [2005]; Graf et al.”
• Neuroligins determine synapse maturation and function. (2006, methodology): “…NL 1 and NL 2 splice isoforms are targeted to and induce inhibitory and excitatory synapses, respectively (Chih et al., 2006), and knock-down of individual NLs by RNAi or dominant-negative NLs cause comparable reductions of synapse numbers in neuron cultures (Chih et al., 2005; Nam and Chen, 2005).”
• Interneuron dysfunction in psychiatric disorders (2012, background): “Neuroligin–neurexin complexes promote both glutamatergic and GABAergic synapse formatio”
• Neuroligins and neurexins link synaptic function to cognitive disease (2008, result): “This conclusion is consistent with the finding that a partial knockdown of the mRNAs encoding NLGNs in cultured neurons produced a partial decrease in synapse numbers that could have been a secondary consequence of a decrease in synaptic functio”
• Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. (2007, positive): “…overexpression of NL1 increased the frequency and amplitude of both excitatory and inhibitory spontaneous miniature postsynaptic currents (‘‘minis’’) (Chih et al., 2005; Levinson et al., 2005; Nam and Chen, 2005; Prange et al., 2004), and that RNAi-mediated knockdown of NL1 and NL2 each…”
• A light-stimulated synaptic device based on graphene hybrid phototransistor (2017, positive): “This dynamical behavior well reproduces an IPSC process observed in biological inhibitory syn­ apse [35], a representative feature of STP.”
• Neurexin-neuroligin signaling in synapse development. (2007, background): “Neuroligins induce formation of glutamatergic and GABAergic presynaptic specializations, with neuroligin 2 being relatively more active on GABAergic axons [3 ,5 ,35].”