Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

By J. Leutgeb, Stefan Leutgeb, May-Britt Moser, Edvard I. Moser. 2007

1,694 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience, Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Developmental Neuroscience

In Neuroscience

Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, background): “Subjects intentionally learnt premise associations between overlapping pairs of objects (i.e., AB, BC, XY, YZ) in a single exposure and were not required to choose a stimulus during the study period.”
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, positive): “Recent experimental evidence also supports the pattern separation function of the dentate gyrus in information processin”
Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Dentate granule cells also outnumber pyramidal cells in entorhinal cortex, but here the expansion ratio is an order of magnitude smaller (approximately 1:5; Leutgeb et al., 2007).”
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis (2011, background): “In such a case, interference may appear in other layers, such as the CA3, but that may be solved by an encoding mechanism separate from neurogenesis (Hasselmo, 2006; Leutgeb et al. , 2007; Myers & Scharfman, 2009).”
Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells (2018, background): “The DG exhibits sparse neural activity wherein only a small fraction of the principal granule cells (GCs) are active at any given time and active GCs have generally low firing rates (Jung and McNaughton, 1993; Chawla et al., 2005; Leutgeb et al., 2007; Neunuebel and Knierim, 2012).”
Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events (2015, background): “…lesioned rats (Kesner et al. 2000; Brun et al. 2002) have demonstrated crucial roles of the trisynaptic pathway in spatial learning and in several other features of episodic memory, such as pattern completion and separation (Marr 1971; Nakazawa et al. 2002; Leutgeb et al. 2007; McHugh et al. 2007).”
Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity (2016, background): “DG has been hypothesized to separate two distinct but overlapping patterns through the activation of different granule cells (GCs), through the expression of different firing rates in identical neuronal populations (Deng et al., 2010) or a combination of the two.”
The mechanisms for pattern completion and pattern separation in the hippocampus (2013, background): “Associative recall by pattern association in the CA3 to CA1 feed forward connections is a prominent property which implements generalization, so that if completion in CA3 was not perfect, CA1 could generalize to the closest CA1 representation (Rolls, 1995, 2008; Schultz et al., 2000).”
Pattern Separation in the Dentate Gyrus: A Role for the CA3 Backprojection (2010, methodology): “Adapted from Leutgeb et al. (2007) Figure 3A.”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, positive): “Another study has found that small changes in the environment explored by rats resulted in large changes in the firing patterns and correlations of DGCs even when grid fields recorded from the perforant path did not change their firing rates (Leutgeb et al., 2007).”
CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation (2014, background): “Consistent with published examples from other groups (Jung and McNaughton, 1993; Leutgeb et al., 2007), tetrode tracks that terminated in the granule cells layer or at the interface between the granule cell layer and the polymorphic layer were considered (for descriptive purposes ) to be located in…”
Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis (2010, background): “The DG has a crucial role in learning and memory [1,2,3].”