Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

By M. Ingelsson, H. Fukumoto, K. Newell, J. Growdon, E. Hedley‐Whyte, Matthew P. Frosch, M. Albert, Bradley T. Hyman, M. Irizarry. Neurology, 2004

687 citations recorded by the source corpus.

Subfields: Physiology, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/9fe5847df851967d16d13d5cadec8cc5e27900b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. M. Pekny
2. M. Pekna
3. Reisa A. Sperling
4. Clifford R. Jack Jr.
5. Alexei Verkhratsky
6. E. Hol
7. M. Carillo
8. William H. Thies

In Psychiatry and Mental health

1. Reisa A. Sperling
2. Clifford R. Jack Jr.
3. William H. Thies
4. David S. Knopman

In Radiology, Nuclear Medicine and Imaging

1. Daniel Rueckert
2. Reisa A. Sperling
3. Clifford R. Jack Jr.
4. Marilyn S. Albert
5. Arvid Lundervold

Citations in the corpus

• Astrocytes: a central element in neurological diseases (2016, background): “Interestingly, the appearance of reactive astrocytes in the human brain, as measured by GFAP expression, coincides with the occurrence of dementia [97, 111].”
• Introduction to Revised Criteria for the Diagnosis of Alzheimer’s Disease: National Institute on Aging and the Alzheimer Association Workgroups (2011, background): “[44] Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-”
• Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease (2016, neutral): “Given extant models (8, 9) and limited autopsy-based empirical data (13-15) it was hypothesized that tau would be a stronger predictor of cognition than Aβ owing to its place later in preclinical disease course.”
• Multi-Method Analysis of MRI Images in Early Diagnostics of Alzheimer's Disease (2011, background): “However, there is evidence that the number of amyloid plaques reach their saturation levels already by the time patients have clinically apparent symptoms of cognitive impairment [8,9], whereas atrophy, neuronal loss, synaptic loss, and the number of tangles increase with severity of illness [10].”
• Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence? (2015, background): “…with the presence of extracellular senile plaques consisting of β amyloid (Aβ) and intraneuronal neurofibrillary tangles consisting of aggregated tau (Grundke-Iqbal et al., 1986; Ingelsson et al., 2004), which first appear in the hippocampus and then spread as the disease progresses.”