Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

By I. Wertz, Saritha Kusam, Cynthia Lam, T. Okamoto, W. Sandoval, Daniel J. Anderson, Elizabeth Helgason, J. Ernst, M. Eby, Jinfeng Liu and 17 more. Nature, 2011

781 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9fd732591b08d4c1d73ee86aec227e857898bbc2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Beth A. Weaver
2. Douglas R. Green

In Molecular Biology

1. F. Llambi
2. Douglas R. Green
3. Beth A. Weaver
4. Guido Kroemer
5. L. Galluzzi
6. J. Wells
7. Olivier Julien
8. Jerry M. Adams

In Oncology

1. Beth A. Weaver
2. Douglas R. Green
3. A. Damjanović
4. F. Llambi
5. M. Nedeljković

Citations in the corpus

• How Taxol/paclitaxel kills cancer cells (2014, background): “These have identified a diverse array of candidates, including proteasome subunits, cyclin G1, and solute carrier genes (Rouzier et al., 2005; Swanton et al., 2007; Whitehurst et al., 2007; Pusztai et al., 2009; Juul et al., 2010; Wertz et al., 2011; Njiaju et al., 2012; Russell et al., 2012).”
• Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge (2019, background): “There are reports linking MCL-1 expression with chemoresistance [126].”
• Cell Death Signaling. (2015, background): “These phosphorylation events unveil a degron on Mcl1 that recruits the SCF-Fbw7 ubiquitin ligase complex, thus targeting Mcl1 for ubiquitylation and degradation (Wertz et al. 2011).”