Phosphorylation of collapsin response mediator protein-2 by Rho-kinase : evidence for two separate signaling pathways for growth cone collapse

By 有村奈利子. 2003

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Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival. (2013, background): “Either way, the formation of dendrites and synapses and the resultant competition for synaptic space appears to be a limiting step in the integration and subsequent survival of new-born neurons (Bergami and Berninger, 2012).”
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly (2002, unknown): “We found that CRMP-2 is phosphorylated by Rho-kinase (an effector of the small GTPase Rho) during the lysophosphatidic-acid-induced growth-cone collapse in dorsal root ganglia neurons and that this phosphorylation is essential for the lysophosphatidic-acid-induced collaps”
Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity (2010, background): “Phosphorylation of CRMP-2 is increased by stimulation with LPA and ephrin-A5 in DRG and hippocampal neurons, respectively, and is implicated in growth cone collapse induced by these repulsive cues [Arimura et al., 2000; Arimura et al., 2005].”