Multistability in the lactose utilization network of Escherichia coli

By Ertugrul M. Ozbudak, Mukund Thattai, Han N. Lim, Boris I. Shraiman, Alexander van Oudenaarden. Nature, 2004

1,080 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9f8dc7e37b179bdc35d631fbd61d7bf6face4b39

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

The second wave of synthetic biology: from modules to systems (2009, background): “Synthetic transcriptional cascades, for example, attenuate noise under some conditions and amplify noise under other”
Stochastic gene expression and its consequences (2008, background): “…following up on the pioneering studies of Novick and Weiner, researchers found that the lactose utilization network in E. coli displayed an " all or none " type of behavior and that single cells stochastically transition between these two states (Mettetal et al., 2006; Ozbudak et al., 2004).”
Dynamic Properties of Network Motifs Contribute to Biological Network Organization (2005, background): “(responsible for lactose utilization and chemotaxis, respectively) are of this sort [”
High-dimensional switches and the modeling of cellular differentiation (2004, background): “99, and Theise and Krause, 2002). Bistable switches have been given a thorough theoretical investigation (Cherry and Adler, 2000), and have been constructed de novo (Gardner et al., 2000) or modiﬁed (Ozbudak et al., 2004). There is evidence, discussed in section 2.1, that cells undergoing diﬀerentia”
How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria (2006, background): “Several mathematical models that describe the expression of the lac operon exist (626, 776, 802, 953, 978, 979).”
Stochasticity in gene expression: from theories to phenotypes (2005, background): “Stochasticity in gene expression can cause random transitions between the two states, yielding bimodal population distribution”
Network resilience (2020, background): “ered in cell differentiation [285, 286, 287], lysogenylytic switch in bacteriophage λ [314], Immune stress response [288], the lactose utilization network in Escherichia coli [339] and so on.”
Bistability, epigenetics, and bet-hedging in bacteria. (2008, background): “The hysteretic behavior of the multistable lactose utilization network is a result of the stability and abundance of the lactose permease (79, 107).”