DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

By M. Robert, Steves Morin, N. Beaulieu, France Gauthier, I. Chute, Annie Barsalou, A. Macleod. Nature Genetics, 2003

642 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9f6fbc86a2b4e69ae6e69c13f73f424e0b47d78f

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In Molecular Biology

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2. Partha M. Das
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4. Yi Zhang

Citations in the corpus

• DNA methylation and cancer. (2004, background): “Si RNA could also be used to target a protein that contributes to methylation-mediated gene repression.(124) Because DNA methylation represses gene expression in part through histone deacetylation, HDAC inhibitors have been used to activate expression from methylated genes.”
• Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b (2003, result): “showed that selective depletion of DNMT1 alone by using antisense or siRNA in HCT116 and other human cancer cell lines resulted in global and gene-specific demethylation (36), a finding consistent with the current view that DNMT1 is the major maintenance enzyme.”