Managing protein flexibility in docking and its applications.

By C. B‐Rao, J. Subramanian, Somesh D. Sharma. 2009

227 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Virtual screening: an endless staircase? (2010, background): “Although much progress has been made in the generation of potential ligand 'poses' by automated docking, the scoring functions used for prioritization of the various suggested poses are still grossly inaccurat”
Computational Methods in Drug Discovery (2014, background): “Conformational variability is seen in unbound form and different apo structures (B-Rao et al., 2009; Sinko et al., 2013).”
Protein-ligand docking in the new millennium--a retrospective of 10 years in the field. (2013, background): “However, their scope is rather limited to small scale rearrangements associated to side-chain plasticity, without the corresponding backbone adjustment [62, 68].”