A role for mitochondria in NLRP3 inflammasome activation
By Rongbin Zhou, A. Yazdi, P. Menu, J. Tschopp. Nature, 2011
3,709 citations recorded by the source corpus.
Subfields: Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9f2d4e9e8872e1431ca1b168991d52c4c83924d9
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In Epidemiology
- Douglas R. Green
- Guido Kroemer
- L. Galluzzi
- Beth Levine
- V. Deretic
- Guillermo Mariño
- Navdeep S. Chandel
- D. Rubinsztein
In Molecular Biology
- Douglas R. Green
- Guido Kroemer
- L. Galluzzi
- Navdeep S. Chandel
- J. Tschopp
- M. Lamkanfi
- V. Dixit
- V. Deretic
Citations in the corpus
- Signal transduction by reactive oxygen species (2011, background): “In particular, several recent reports have identified a critical role for mitochondrial oxidants in the formation of the NLRP3 (NOD-like receptor pyrin domain-containing 3) inflammasome (Bulua et al., 2011; Nakahira et al., 2011; Zhou et al., 2011).”
- Metabolic Pathways In Immune Cell Activation And Quiescence (2013, background): “…key role of mitochondria in this process has been demonstrated by the inhibition of inflammasome activation and IL-1b and caspase 1 production by inhibitors of mitochondrial ROS, but not by inhibitors of NADPH-oxidase-dependent ROS (Bulua et al., 2011; van Bruggen et al., 2010; Zhou et al., 2011).”
- Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “A possible mechanism for NLRP3 inflammasome activation is the accumulation of damaged, ROS-generating mitochondria (Misawa et al., 2013; Zhou et al., 2011).”
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “The role of mitochondrial ROS (mtROS) in NLRP3 inflammasome activation was originally proposed from a study showing that mtROS, as generated by the inhibition of the mitochondrial respiratory chain, can activate the NLRP3 inflammasome [97].”
- Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) (2011, background): “Although it has recently been shown that mitochondrial damage and inhibition of mitophagy can activate the NLRP3 inflammasome and IL-1 cleavage in a ROS-dependent manner (Zhou et al., 2010b), our results suggest a more general role for mitochondrial ROS in the induction of inflammatory cytokines up”