Crystal structure of parallel quadruplexes from human telomeric DNA

By G. Parkinson, Michael P. H. Lee, Stephen Neidle. Nature, 2002

1,849 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9f1f0fabba1647916fc52d2b0766670b0176291a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Stability and kinetics of G-quadruplex structures (2008, methodology): “This general approach, in conjunction with other spectroscopic data, was used to demonstrate that the widely used X-ray crystal structure of the human telomere (99) is not the dominant form in free dilute solution (61).”
Prevalence of quadruplexes in the human genome (2005, positive): “Telomeric repeats in a variety of organisms (3,4) have been shown to form these structures in vitro and high-resolution structures of the human telomeric sequence d(T2AG3)n have been solved by NMR spectroscopy (5) and X-ray crystallography ( 6 ).”
G-quadruplexes and their regulatory roles in biology (2015, background): “Knowledge of the precise 3D-structure (6) is important for the design of G-quadruplex stabilizing ligands used for probing the consequences of G-quadruplex stabilization on processes such as DNA replication and gene transcription, and as anticancer drugs to target Gquadruplexes in the promoters of o”
The Structure and Function of DNA G-Quadruplexes (2020, background): “Structural studies using X-ray crystallography and NMR spectroscopy have provided detailed insights into the structure of DNA G4s primarily based on the human telomeric repeat (Figure 1B,C) [11] or sequences derived from the promoter regions of certain human genes such as MYC or KIT [12,13].”
Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics (2007, background): “These very different conformers reported for the fourrepeat human telomeric sequence in Na-containing aqueous solution (9) and in K-containing crystals (17) appear to highlight the polymorphic character of G-quadruplex scaffolds (93) as a function of medium and/or monovalent cation type.”
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution (2006, background): “NMR structure studies have been reported on two dimeric G-quadruplexes of human telomeric sequences in K+ solution (38,39); however, the intact unimolecular G-quadruplex structure formed in the human telomeric sequence in K+ solution has yet to be determined.”
Circular dichroism and conformational polymorphism of DNA (2009, methodology): “The final spectrum corresponds to parallel quadruplex observed in the crystal (93).”
Quadruplex DNA: sequence, topology and structure (2006, background): “This feature has been found both in crystal structures (22) and in solution (23) for quadruplexes formed from human telomeric DNA sequences (see below), and more recently in a number of non-telomeric quadruplexes.”
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription (2006, methodology): “As DMS-footprinting data do not give information about the topology of the loops, the three loops may be either all external (propeller conformation), as found in the telomere d[AGGG(TTAGGG)3] repeat in the crystalline state (34), or two external and one diagonal, as depicted in the structures of Fi”