Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

By Nick Barker. Nature reviews. Molecular cell biology, 2013

1,254 citations recorded by the source corpus.

Subfields: Biotechnology, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/9f009b3faac568788cd636b5506d033597dc3df5

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Citations in the corpus

Spatiotemporal analysis of human intestinal development at single-cell resolution (2021, neutral): “15 epithelial clusters were identified and annotated by their gene expression profile as; Enteroendocrine cells (CHGA, TPH1 and NEUROD1) (Gehart et al., 2019), transit-amplifying cells (MKI67, UBE2C and TOP2A) (Parikh et al., 2019), enterocytes (FABP2, CEACAM1 and EPCAM) (Dalerba et al., 2011), gobl”
The Hippo signaling pathway in stem cell biology and cancer (2014, neutral): “Intestinal stem cells (ISCs) are responsible for the constant renewal and repair of the intestinal epithelia to maintain tissue homeostasis [125,126].”
New developments in goblet cell mucus secretion and function (2015, neutral): “In the small intestine, with its larger epithelial surface, cell renewal takes between 3 and 5 days.(23) Investigation of this region using the same method demonstrated that crypt goblet cells were labeled very slowly, but massive secretion was observed at the crypt opening a few hours after GalNAz ”
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD (2019, background): “The intestinal epithelium, which separates the luminal content from the mucosal immune system, is an important defensive line to protect the homeostasis of the gut microbiota and minimize intestinal inflammatory responses [8].”
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease (2018, background): “However, other reserve stem cell markers (Barker, 2014), such as LRIG1, HOPX, BMI1, PROM1, EPHB2, and KLF4, showed little or no change compared to untreated epithelial organoids (data not shown).”