Host-Gut Microbiota Metabolic Interactions

By Jeremy K. Nicholson, Edward C. Holmes, James Kinross, R. Burcelin, G. Gibson, W. Jia, S. Pettersson. Science, 2012

4,333 citations recorded by the source corpus.

Subfields: Gastroenterology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9ef2a1382b03bc3c914a2f6d0f0fd77dbbb87499

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Citations in the corpus

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota (2017, positive): “Gut Microbiota Orchestrates EODF-Induced WAT Beiging Recently, correlative evidence revealed a metabolic interaction between the gut microbial communities and the host, and gut bacteria have an important role in the regulation of brown and beige adipose tissues (Chevalier et al., 2015; Holmes et al.”
Gut Microbiota and Immune System Interactions (2020, background): “Moreover, both increased mucosa-associated bacterial abundance and translocation of bacteria to the mesenteric lymph nodes, in addition to altered bacterial composition, are associated with loss of MyD88 signaling in epithelial cells [75,76].”
The gut microbiota influences blood-brain barrier permeability in mice (2014, background): “Our gut microbiota is important for many biological functions in the body, including intestinal development, barrier integrity and function (1, 2), metabolism (3, 4), the immune system (5), and the central nervous system (CNS).”
Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity (2014, background): “, SCFA), which present with beneficial functions (54), were not different between AD and control subjects and unrelated to IP.”
The Potential Use of Probiotics to Improve Animal Health, Efficiency, and Meat Quality: A Review (2020, background): “The gut microbiota is known to interact with the host immune system [29].”
Animals in a bacterial world, a new imperative for the life sciences (2013, background): “…carried in its blood — has a microbial origin; thus, the circulatory system extends the chemical impact of the microbiota throughout the human body (79), transporting metabolites that in ﬂ uence the physiology and metabolism of distant organs and perhaps other bacterial communities (80, 81).”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “…ranging from basic microbiology to translational applications (e.g. see Bercik et al. 2012; Berer & Krishnamoorthy 2012; Collins et al. 2012b, 2013; Cryan & Dinan 2012; Cryan & O’Mahony 2011; Forsythe & Kunze 2013; Lyte 2011, 2013; Nicholson et al. 2012; Rhee et al. 2009; Sommer & Bäckhed 2013).”
Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. (2012, background): “An alternative conceptualization is an idealized collection of genes and pathways rather than specific populations; although, a ‘‘healthy’’ set of metabolic functions remains to be defined (Nicholson et al., 2012).”
Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes (2015, background): “The interactions, and sometimes intertwining, of genomes and gene products between the host and microbiota can carry out many functions of a hologenome, such as the synthesis of essential amino acids [69], chemosynthesis [70], or metabolite production [71].”
Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics (2016, background): “For instance, it is well known that bacteria aid in many importantmetabolic pathways, including synthesis of essential compounds like secondary bile acids and short-chain fatty acids (Flint et al., 2012; Nicholson et al., 2012).”
Small Molecules from the Human Microbiota (2015, positive): “microbiota-derived metabolites in a variety of sample types and disease models, developing powerful and widely applicable analytical pipelines (131, 132) (Fig.”