FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain.

By T. Palmer, J. Ray, Fred H. Gage. 1995

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Citations in the corpus

Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS (1999, methodology): “Vimentin, a marker attributed to ependymal cells, immature astrocytes, and radial glia, is also known to be expressed by multipotent precursors in perpetualized neural precursor cultures (Levison and Goldman, 1993; Palmer et al., 1995; Luskin et al., 1997).”
Substrate modulus directs neural stem cell behavior. (2008, methodology): “To determine the ability of vmIPNs to support multipotent differentiation, we seeded aNSCs in media containing 1 v/v % FBS, a condition shown to drive astrocytic differentiation on hard surfaces (24,40).”
Neurogenesis in the Adult Brain (2002, background): “…and Weiss, 1992; Richards et al., 1992) and then in the dentate gyrus of the hippocampus (Gage et al., 1995; Palmer et al., 1997), and in most structures of the brain examined (Palmer et al., 1995; Shihabuddin et al., 2000), even where no neurons existed (Palmer et al., 1999; Kondo and Raff, 2000).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Two mitogens widely used to culture neural stem cells in vitro either as neurospheres or as adherent monolayers are epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) (Reynolds & Weiss 1992; Palmer et al. 1995).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “1999), optic nerve, septum, corpus callosum, spinal cord, retina and hypothalamus (Palmer et al. 1995; Weiss et al. 1996a; Shihabuddin et al. 1997; Palmer et al. 1999; Tropepe et al. 2000; Lie et al. 2002).”
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus (2000, background): “…cells are affected by age, growth factors, excitatory input, adrenal steroids, seizures, and enrichment of the environment (Cameron and Gould, 1994; Palmer et al., 1995; Craig et al., 1996; Kuhn et al., 1996; Bengzon et al., 1997; Gould et al., 1997; Kempermann et al., 1997; McKay, 1997; Nilsson…”
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential (2002, background): “Endothelial cells proliferate within the CNS (Horner et al., 2000; Palmer et al., 2000), and our preliminary results indicate that indeed some of the BrdU-labeled cells colocalize with endothelial cell markers (data not shown).”
Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus (2000, background): “FGF-2 appears to be a mitogen for both unipotent and multipotent progenitors (Murphy et al., 1990; Ray et al., 1993; Kilpatrick and Bartlett, 1995; Palmer et al., 1995, 1997; Gritti et al., 1996; Kalyani et al., 1997; Mujtaba et al., 1998).”
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum (2006, background): “Previous in vitro studies have revealed that cells isolated from the striatum can generate new neurons when stimulated by intrinsic or extrinsic factors (Palmer et al., 1995; Wang et al., 2004), suggesting that latent neural progenitor cells reside in the striatal parenchyma.”