Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex

By K. Blanc, L. Tammik, B. Sundberg, S. Haynesworth, O. Ringdén. Scandinavian Journal of Immunology, 2003

1,383 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/9ea29eb369842ebeb57f5f96896af1da46217785

How researchers see this paper

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In Genetics

1. A. Caplan
2. R. Lee
3. O. Ringdén
4. C. Gregory
5. L. Meirelles
6. Jeffrey L Spees
7. W. Fibbe

In Hematology

1. A. Caplan
2. O. Ringdén

In Oncology

1. A. Caplan
2. O. Ringdén

Citations in the corpus

• Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells (2003, background): “The finding that MSCs escape recognition by CTLs is surprising because MSCs express HLA class I antigens, which are targets for CTL lysis (7).”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “Some of the first evidence that MSCs could actively blunt immune responses originated from the results of mixed lymphocyte reaction (MLR) assays performed ex vivo [30–36].”