Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

By S. Keyse. Current Opinion in Cell Biology, 2000

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Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. (2007, background): “For other recent reviews on the roles of phosphatases in MAPK signaling, see [332,333].”
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases (2007, background): “The catalytic domain, which contains the characteristic cysteine-dependent protein tyrosine phosphatase active site sequence I/VHCXAGXXR, is related in sequence to the prototypic VH-1 dualspecificity phosphatase encoded by vaccinia virus (Camps et al., 2000; Keyse, 2000).”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “In addition, functional analyses employing knockdown of MKP3, a member of the subfamily of protein tyrosine phosphatases known as dual-specificity phosphatases (MKPs) [269,270], and ectopic overexpression revealed the role of MKP3 in negatively regulating ERK1/2 activity and inhibiting tumorigenicit”
MAPK phosphatases — regulating the immune response (2007, background): “Because this group of MKPs is rapidly induced by many of the same stimuli that activate MAPKs, for example growth factors and stress, it has been proposed that these MKPs function as a feedback control mechanism for MAPK signallin”