CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

By E. Haapaniemi, Sandeep K Botla, Jenna Persson, Bernhard Schmierer, Jussi Taipale. Nature Medicine, 2018

1,094 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9e449274b3e69f5d78d924179d96a4941932b19b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jonathan S. Weissman
2. C. Hetz
3. G. Hotamışlıgil

In Molecular Biology

1. Eric J. Wagner
2. Doron Lipson
3. Jonathan S. Weissman
4. K. Adelman
5. Nicholas T. Ingolia
6. Debashish Chowdhury
7. Jennifer A. Doudna

Citations in the corpus

• CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future (2020, background): “Thus, successful CRISPR edits are more likely to occur in p53 suppressed cells, resulting in a bias toward selection for oncogenic cell survival (70).”
• Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq (2021, positive): “(4) Unlike CRISPR knockout, CRISPRi does not lead to activation of the DNA damage response which can alter transcriptional signatures (Haapaniemi et al., 2018).”