Nanoparticle-based protein detection by optical shift of a resonant microcavity

By M. Santiago-Cordoba, Svetlana V. Boriskina, Frank Vollmer, M. Demirel. 2002

1,056 citations recorded by the source corpus.

We demonstrated a biosensing approach which, for the first time, combines the high sensitivity of whispering gallery modes (WGMs) with a metallic nanoparticle-based assay. We provided a computational model based on generalized Mie theory to explain the higher sensitivity of protein detection. We quantitatively analyzed the binding of a model protein (i.e., Bovine Serum Albumin) to gold nanoparticles from high-Q WGM resonance frequency shifts, and fit the results to an adsorption isotherm, which agrees with the theoretical predictions of a two-component adsorption model. V C 2011 American Institute of Physics. [doi:10.1063/1.3599706]

Subfields: Atomic and Molecular Physics, and Optics, Biomedical Engineering, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/9e1923025c45db8ba838cc2cd074f2ed9868c1e3

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In Atomic and Molecular Physics, and Optics

In Biomedical Engineering

In Electrical and Electronic Engineering

Citations in the corpus

Biosensors for Protein Detection: A Review (2005, methodology): “An optical biosensor was reported for detection of label-free molecules based on optical resonances in a transparent dielectric microparticle (whispering galley modes) as physical transduction (Vollmer et al. 2002).”
Design guidelines for optical resonator biochemical sensors (2009, background): “ecently there has been an increasing interest in employng dielectric optical microresonators (resonant or optical avities) as miniaturized biochemical sensors, and such a ensing mechanism has been demonstrated by using a umber of resonator devices, including microspheres [1], icrorings [2–4], microd”
Ligand–receptor interaction platforms and their applications for drug discovery (2012, background): “5 Whispering gallery microresonators Whispering gallery microresonator (WGM) is also an evanescent wave-based biosensor that uses spherical or circular microresonators or resonant cavities having high quality factors (Q factors) to confine light, generating very sharp resonances for the light that p”
Optofluidic Microsystems for Chemical and Biological Analysis (2011, background): “OFRRs retain the excellent sensing capability of ring resonators 48 while also being integrated microfluidic structures.”