Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.

By D. Blackwood, A. Fordyce, M. Walker, D. S. Clair, D. Porteous, W. Muir. American Journal of Human Genetics, 2001

783 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9e0244ec882560cdb7f4f04c28a4f82af54569b1

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In Genetics

1. Guo-li Ming
2. Hongjun Song
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4. Fred H. Gage
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1. Hongjun Song
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Citations in the corpus

• DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, positive): “DISC1 was originally identified at the breakpoint of a balanced (1;11) (q42;q14) chromosome translocation that cosegregates with schizophrenia, bipolar disorder, and recurrent major depression in a large Scottish family (Blackwood et al., 2001; Millar et al., 2000).”
• Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies (2009, background): “Usually, DISC1 is considered to be a major risk gene for schizophrenia but affected individuals in this family displayed a range of diagnoses, with the majority being diagnosed with either schizophrenia or MDD [Blackwood et al., 2001; Hashimoto et al., 2006].”
• DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009, background): “3) translocation allele of the DISC1 gene closely segregates with the manifestation of psychiatric disorders in a large Scottish pedigree (Blackwood et al., 2001).”
• Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, background): “Implications for Mental Disorders disc1 was initially identified as a gene disrupted by a balanced translocation on chromosome 1q42 that segregates with schizophrenia, bipolar disorder, and recurrent major depression in a large Scottish family (Blackwood et al., 2001; Millar et al., 2000).”
• Disrupted-in-Schizophrenia-1 (2008, background): “Adding in minor illnesses decreased the LOD score dramatically [9].”