Notch signalling in context

By S. Bray. Nature reviews. Molecular cell biology, 2016

916 citations recorded by the source corpus.

The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes. With a direct route from the membrane to the nucleus, the Notch pathway has fewer opportunities for regulation than do many other signalling pathways, yet it generates exquisitely patterned structures, including sensory hair cells and branched arterial networks. More confusingly, its activity promotes tissue growth and cancers in some circumstances but cell death and tumour suppression in others. Many different regulatory mechanisms help to shape the activity of the Notch pathway, generating functional outputs that are appropriate for each context. These mechanisms include the receptor–ligand landscape, the tissue topology, the nuclear environment and the connectivity of the regulatory networks.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9da82ce7c8e37e359767f260ca03e21c3df323c0

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In Molecular Biology

Citations in the corpus

Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “Dll4 binds Notch1 in neighboring ECs, leading to the cleavage and release of the Notch1 intracellular domain (NICD) [9].”
PI5P4Kγ functions in DTX1-mediated Notch signaling (2018, background): “T Notch signaling pathway is central to processes ranging from cell-fate specification to cell viability (1).”
Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “Thus, the bidirectional transitions between EMT and MET states are potentiated by the ZEB/miR-200 circuit (Bracken et al , 2008; Burk et al , 2008; Wellner et al , 2009).”