Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections.

By G. Pankey, L. Sabath. Clinical Infectious Diseases, 2004

1,182 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/9d6fb47af1d40657aa2d9e42dab9253b977f2e14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Robert E. W. Hancock
2. James J. Collins
3. Michael R Hamblin

In Molecular Medicine

1. James J. Collins
2. Robert E. W. Hancock
3. Michael R Hamblin

In Pharmacology

1. Robert E. W. Hancock
2. James J. Collins
3. K. Hilpert
4. I. Wiegand
5. Michael R Hamblin

Citations in the corpus

• Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances (2008, background): “Factors that affect the response to therapy are far more complex and include host defense mechanisms, underlying diseases of the patient, the site of infection, and the pharmacokinetic and pharmacodynamic properties of the drug”
• Antibiotic efficacy is linked to bacterial cellular respiration (2015, background): “Although the clinical value of bactericidal activity in the treatment of infection is a point of debate (1, 2), evidence supports a preference for bactericidal antibiotics for certain highrisk infections (2–8).”
• The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli. (2012, methodology): “We confirmed the bactericidal property of gold NPs via testing the MBC/MIC value according to reported methods [32,33].”
• A common mechanism of cellular death induced by bactericidal antibiotics. (2007, neutral): “Current antimicrobial therapies, which cover a wide array of targets (Walsh, 2003), fall into two general categories: bactericidal drugs, which kill bacteria with an efficiency of >99.9%, and bacteriostatic drugs, which merely inhibit growth (Pankey and Sabath, 2004).”
• Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. (2013, background): “Antibiotics can be divided into two broad classes: bacteriostatic drugs that inhibit bacterial growth (Pankey & Sabath, 2004) and bactericidal drugs that kill bacteria.”